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Nitrates - Administration of Tadalafil to patients who are using any form of organic nitrate, either regularly and/or intermittently, is contraindicated. In clinical pharmacology studies, tadalafil was shown to potentiate the hypotensive effect of nitrates. This is thought to result from the combined effects of nitrates and tadalafil on the nitric oxide/cGMP pathway.

Alpha Blockers - Administration of Tadalafil to patients taking any alpha-adrenergic antagonist other than 0.4 mg once-daily tamsulosin is contraindicated. In a drug-drug interaction study, when tadalafil 20 mg was administered to healthy subjects taking doxazosin (8 mg daily), there was a significant augmentation of the blood-pressure-lowering effect of doxazosin.

Hypersensitivity - Tadalafil is contraindicated for patients with a known hypersensitivity to tadalafil or any component of the tablet.

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